Shahrood University of Technology Journal of AI and Data Mining 2322-5211 10 2 2022 04 01 Automatic Detection of Lung Nodules on Computer Tomography Scans with a Deep Direct Regression Method 207 215 2404 10.22044/jadm.2022.11431.2303 EN Kh. Aghajani Department of Computer Engineering, University of Mazandaran, Babolsar, Iran. Journal Article 2021 12 02 Deep-learning-based approaches have been extensively used in detecting pulmonary nodules from computer Tomography (CT) scans. In this study, an automated end-to-end framework with a convolution network (Conv-net) has been proposed to detect lung nodules from CT images. Here, boundary regression has been performed by a direct regression method, in which the offset is predicted from a given point. The proposed framework has two outputs; a pixel-wise classification between nodule or normal and a direct regression which is used to determine the four coordinates of the nodule's bounding box. The Loss function includes two terms; one for classification and the other for regression. The performance of the proposed method is compared with YOLOv2. The evaluation has been performed using Lung-Pet-CT-DX dataset. The experimental results show that the proposed framework outperforms the YOLOv2 method. The results demonstrate that the proposed framework possesses high accuracies of nodule localization and boundary estimation. https://jad.shahroodut.ac.ir/article_2404_962b19fbf305454704f8841902329eff.pdf