In this study, the energy consumption in the food and beverage industries of Iran was investigated. The energy consumption in this sector was modeled using artificial neural network (ANN), response surface methodology (RSM) and genetic algorithm (GA). First, the input data to the model were calculated according to the statistical source, balance-sheets and the method proposed in this paper. It can be seen that diesel and liquefied petroleum gas have respectively the highest and lowest shares of energy consumption compared with the other types of carriers. For each of the evaluated energy carriers (diesel, kerosene, fuel oil, natural gas, electricity, liquefied petroleum gas and gasoline), the best fitting model was selected after taking the average of runs of the developed models. At last, the developed models, representing the energy consumption of food and beverage industries by each energy carrier, were put into a finalized model using Simulink toolbox of Matlab software. Results of data analysis indicated that consumption of natural gas is being increased in Iran food and beverage industries, while in the case of fuel oil and liquefied petroleum gas a decreasing trend was estimated.